EPA releases July 2025 TSCA Inventory

On August 14, 2025, the Environmental Protection Agency (EPA) released the biannual update to the nonconfidential Toxic Substances Control Act (TSCA) Chemical Substance Inventory (TSCA Inventory). The inventory includes all TSCA-regulated chemical substances manufactured, processed, or imported in the U.S.

Adding 15 chemical substances since the last update, the July 2025 TSCA Inventory contains 86,862 chemicals. Nearly half of the substances (42,578) are active (i.e., in use). EPA also updated:

• Commercial activity data,
• Unique identifier data, and
• Regulatory flags (which identify substances with manufacturing or use restrictions as well as substances with full or partial reporting exemptions).

Further, the agency updated the TSCA Master Inventory File. It includes chemical identity information claimed as confidential that’s excluded from the nonconfidential TSCA Inventory. The TSCA Master Inventory File is the only list with comprehensive, authoritative information about which chemical substances are on the inventory.

The agency plans to make the next inventory update in Winter 2026.

How do I access the inventory?

View the TSCA Inventory by:

• Downloading the Microsoft Access or CSV text version of the data from EPA’s website, or
• Using EPA’s Substance Registry Services (SRS).

How does this impact my business?

The TSCA Inventory helps facilities determine compliance requirements for chemicals they (a) manufacture or use or (b) plan to manufacture or use. Chemicals that are on the TSCA Inventory are likely subject to rules, like manufacturing limits and reporting requirements. Chemicals that aren’t on the list must meet notification and review requirements before they can be used.

Key to remember: EPA released the July 2025 nonconfidential TSCA Inventory of chemical substances manufactured, processed, or imported in the U.S.