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EPA posts final health assessment for dry-cleaning chemical

Agency confirms perc is a “likely human carcinogen”

Posted February 15, 2012

On February 10, EPA posted the final health assessment for tetrachloroethylene — also known as perchloroethylene, or perc — to EPA’s Integrated Risk Information System (IRIS) database. Perc is a chemical solvent widely used in the dry cleaning industry. It is also used in the cleaning of metal machinery and to manufacture some consumer products and other chemicals. The Agency says the final assessment confirms long-standing scientific understanding and research in characterizing perc as a “likely human carcinogen.” The assessment provides estimates for both cancer and non-cancer effects associated with exposure to perc over a lifetime.

The Agency has already taken several significant actions to reduce exposure to perc including:

  • Clean air standards for dry cleaners that use perc, including requirements that will phase-out the use of perc by dry cleaners in residential buildings by December 21, 2020;
  • Limits for the amount of perc allowed in drinking water and levels for cleaning up perc at Superfund sites throughout the country, which will be updated in light of the IRIS assessment. The toxicity values reported in the perc IRIS assessment will be considered in:
  • Establishing cleanup levels at the hundreds of Superfund sites where perc is a contaminant;
  • Revising EPA’s Maximum Contaminant Level for perc as part of the carcinogenic volatile organic compounds group in drinking water, as described in the agency’s drinking water strategy; and
  • Evaluating whether to propose additional limits on the emissions of perc into the atmosphere, since perc is considered a hazardous air pollutant under the Clean Air Act.

The assessment replaces the 1988 IRIS assessment for perc and for the first time includes a hazard characterization for cancer effects. This assessment has undergone several levels of rigorous, independent peer review including agency review, interagency review, public comment, and external peer review by the National Research Council. All major review comments have been addressed.

In May 2009, EPA streamlined the IRIS process to increase transparency, ensure the timely publication of assessments, and reinforce independent review. In July 2011, EPA announced further changes to strengthen the IRIS program in response to recommendations from the National Academy of Sciences. EPA’s peer review process is designed to elicit the strongest possible critique to ensure that each final IRIS assessment reflects sound, rigorous science.


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